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http://acidophiluspearls.org/

Researchers have uncovered the complete genetic make-up of the
cavity-causing bacterium Bifidobacterium dentium Bd1, revealing the
genetic adaptations
that allow this microorganism to live and cause decay in the human oral
cavity. The study, led by Marco Ventura's Probiogenomics laboratory at the
University of Parma, and Prof. Douwe van Sinderen and Dr Paul O'Toole of
the Alimentary Pharmabiotic Centre at University College Cork, is
published
December 24 in the open-access journal PLoS Genetics.

Bifidobacteria, largely known as long-term beneficial gut bacteria, are
often included as probiotic components of food to aid digestion and boost
the
immune system. However, not all species within the genus Bifidobacterium
provide beneficial effects to the host's health. In fact, the
Bifidobacterium dentium species is an opportunistic pathogen since it has
been linked to the development of tooth decay. The genome sequence of B.
dentium Bd1 reveals how this microorganism has adapted to the oral
environment through specialized nutrient acquisition features, acid
tolerance,
defences against antimicrobial substances and other gene products that
increase fitness and competitiveness within the oral niche.

This report identifies, through various genomic approaches, specific
adaptations of a Bifidobacterium taxon to a lifestyle as a tooth
decay-causing
bacterium. The data in this study indicate that the genome of this
opportunistic pathogen has evolved through only a small number of
horizontal gene
acquisition events, highlighting the narrow boundary that separates
bacteria that are long-term residents on or in the human body from
opportunistic
pathogens.

Financial Disclosure: This work was financially supported by the Italian
Award for Outstanding Young Researcher scheme Incentivazione alla mobilità
di studiosi stranieri e italiani residente all'estero 2005-2009 and a
Marie Curie Reintegration Grant (MERG-CT-2005-03080) to MV; by the Science
Foundation Ireland Alimentary Pharmabiotic Centre located at University
College Cork to DvS, GFF, and PWOT; and by an EMBARK postdoctoral grant to
AZ.
The funders had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.

Competing Interests: The authors have declared that no competing interests
exist.

Citation:
Ventura M, Turroni F, Zomer A, Foroni E, Giubellini V, et al. (2009)
“The Bifidobacterium dentium Bd1 Genome Sequence Reflects Its Genetic Adaptation to the Human Oral Cavity.”

PLoS Genet 5(12): e1000785. doi:10.1371/journal.pgen.1000785

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How to Borrow Money on Prosper About Prosper: Prosper is an online marketplace for person-to-person lending and borrowing. Borrowing money through the Prosper community is fast and …

can I borrow some money

The government has already taken some steps to slow the borrowing binge and has called on banks to scrutinise the viability of projects they are being asked to finance.

Victor Shih, a professor of political science at Northwestern University in the United States, said in a recent report that he had examined 8,000 local government investment entities and concluded they had borrowed the equivalent of $1.6 trillion between 2004 and the end of 2009.

In a report on Thursday, Jing Ulrich, chairman of China equities and commodities at J.P. Morgan, played down fears that a crisis might be brewing.

“Looking ahead, while certain local administrations might struggle to service debt, the magnitude of public sector debt risks do not appear as severe as some have suggested,” she said.

Citing International Monetary fund forecasts, she said China's government debt-to-GDP ratio is projected to reach 22 percent in 2010, compared with 94 percent in the United States and 227 percent in Japan.

“Even if the more alarming estimates of local government debt were included, the ratio would only grow to approximately 51 percent of estimated 2010 GDP,” she said.

Germany has passed its budget for 2010, with borrowing set to soar this year.

New borrowing is expected to reach 80.2 billion euros ($US109 billion) – double the previous highest debt record, set in 1996.

However, the BBC reports this is less than the 85.8 billion euros initially proposed by the government.